Reta
Price range: $200.00 through $325.00
RT (Retatrutide) – a triple GLP-1/GIP/glucagon receptor agonist for research into metabolic coordination, energy balance, and glucose homeostasis.
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Overview
RT (Retatrutide, LY3437943) is a long-acting, acylated synthetic peptide developed as a triple agonist at three distinct incretin and glucagon receptors: GLP-1R (glucagon-like peptide-1 receptor), GIPR (glucose-dependent insulinotropic polypeptide receptor), and GCGR (glucagon receptor). It was engineered through fatty acid acylation to extend its circulating half-life to approximately one week, enabling once-weekly administration in research protocols. In preclinical models, RT has been studied for its ability to coordinate multiple metabolic axes simultaneously — GLP-1R engagement drives insulin secretion and appetite suppression, GIPR engagement enhances glucose-dependent insulin release and may augment GLP-1R activity, and GCGR engagement increases energy expenditure and hepatic glucose output regulation. This triple-receptor coordination has made RT one of the most studied next-generation metabolic peptides in preclinical obesity and diabetes research.
Specification
| CAS Number | 2381089-83-2 |
| Chemical Name | Retatrutide; LY3437943 |
| Peptide Type | Long-acting acylated triple incretin receptor agonist (GLP-1R / GIPR / GCGR) |
| Molecular Formula | C₂₇₂H₄₁₉N⁵₁O₇₉S (acylated peptide) |
| Molecular Weight | ~6329 g/mol |
| Physical Appearance | White lyophilized powder |
| Purity | >99% (HPLC & Mass Spectrometry verified) |
| Verification Method | HPLC & MS |
| Available Sizes | 10 mg, 20 mg, 30 mg, 40 mg |
| Solubility | Soluble in sterile or bacteriostatic water |
| Storage Conditions | 2–8°C; protect from light; long-term −20°C |
| Intended Use | Laboratory research use only (RUO) |
| COA Availability | Lot-specific COA provided per batch |
Potential Research Applications
RT (Retatrutide) is one of the most advanced multi-receptor agonist peptides in preclinical metabolic research. Its simultaneous engagement of three incretin/glucagon receptors enables investigation of coordinated metabolic effects that single or dual-agonist peptides cannot replicate.
Triple Incretin Receptor Pharmacology — Studies examining the simultaneous binding kinetics and downstream signaling of GLP-1R, GIPR, and GCGR in vitro, with RT serving as a pharmacological standard for multi-receptor co-activation research.
Obesity and Body Weight Regulation Research — Rodent and non-human primate models documenting significant reductions in body weight and fat mass, with mechanistic studies examining appetite suppression (GLP-1R), energy expenditure (GCGR), and adipose tissue metabolism.
Glucose Homeostasis and Insulin Secretion Studies — Models investigating glucose-dependent insulin secretion via GLP-1R and GIPR co-activation, hepatic glucose output regulation via GCGR, and overall glycemic control in diabetic and pre-diabetic animal models.
Metabolic Rate and Energy Expenditure Research — Studies examining GCGR-mediated thermogenesis, brown adipose tissue activation, and total energy expenditure, with RT-treated models showing amplified energy expenditure compared to dual GLP-1/GIP agonists.
FAQ
Find answers to common questions about RT (Retatrutide), its triple-agonist mechanism, research applications, and purchasing requirements.
Clinically Proven
Why Choose Telos
Every product we ship is engineered to remove variables and let your data speak for itself.
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cGMP Origin
Peptides are produced in ISO-9001 facilities that follow cGMP principles.
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Triple-Filtered
0.22 µm filtration and gamma irradiation safeguard sterility.
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3rd-Party Tested
Each lot is validated by a third-party lab for purity, identity, and endotoxin.
“For Research Only”
Frequently Asked Questions
✧ 1. What are Telos Health peptides used for?
All Telos Health products are sold for research use only. They are not intended for human consumption, therapeutic, or diagnostic use. Our peptides are designed exclusively for controlled laboratory research, educational studies, or analytical testing. Every product label and supporting document clearly reflects this compliance standard.
✦ 2. Who is eligible to purchase peptides?
Purchases are available to verified professionals, licensed clinics, educational institutions, and qualified research entities. Individuals may also purchase peptides for legitimate research or educational purposes, but all buyers must acknowledge and agree to Telos Wellness’s research-only terms prior to completing any order. We do not sell or endorse products for personal or medical use under any circumstance
♡ 3. How should peptides be handled and stored?
Peptides arrive as a lyophilized (freeze-dried) powder. For laboratory reconstitution, use only sterile bacteriostatic water or sterile saline (0.9 percent NaCl). Gently introduce the solvent and swirl—do not shake. Once reconstituted, store at 35°F to 45°F for short-term use, or at –4°F for long-term preservation. Protect vials from light and moisture, and avoid repeated freeze and thaw cycles to maintain stability.
⟡ 4. Why do peptide vials appear nearly empty?
Because peptides are measured in milligrams, the quantity often appears minimal or as a thin layer within the vial. This is completely normal for high-purity research peptides. Each vial undergoes precision weighing and purity testing using high-performance liquid chromatography (HPLC) and mass spectrometry to ensure the correct labeled amount is present.
✧ 5. What documentation and quality assurances come with each product?
Every peptide includes a Certificate of Analysis (COA) verifying its identity, purity (≥ 99 percent), and composition. Each batch is U.S. sourced and assembled under strict quality oversight and internal auditing. Full lot traceability, validated purity testing, and documentation accompany every shipment to ensure reproducibility, compliance, and scientific reliability.