Semax
$150.00
Semax / XA Semax — a synthetic ACTH(4–10) analogue and its stabilized acetylated form for research into neuroprotection, BDNF signaling, and cognitive function.
✓ 99.9% Purity ✓ Lab Tested ✓ Based in USA
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Overview
Semax (Met-Glu-His-Phe-Pro-Gly-Pro) is a synthetic heptapeptide derived from the ACTH(4–10) fragment of adrenocorticotropic hormone. It was developed at the Institute of Molecular Genetics of the Russian Academy of Sciences and has been studied in CNS research since the 1980s. XA Semax (N-Acetyl Semax Amidate, Ac-Met-Glu-His-Phe-Pro-Gly-Pro-NH2) is a stabilized analogue incorporating an N-terminal acetyl group and a C-terminal amide — modifications that reduce enzymatic degradation by aminopeptidases and carboxypeptidases, significantly extending functional half-life in research preparations. Both forms engage melanocortin and ACTH receptor pathways and are characterized in the literature as potent upregulators of BDNF, NGF, and VEGF in hippocampal and cortical tissue models.
Specification
| CAS Number (Semax) | 80714-61-0 |
| CAS Number (XA Semax) | 80714-61-0 (acetylated amidate form) |
| Chemical Name | Semax: Met-Glu-His-Phe-Pro-Gly-Pro · XA Semax: Ac-Met-Glu-His-Phe-Pro-Gly-Pro-NH2 |
| Peptide Type | Synthetic ACTH(4–10) heptapeptide analogue; neuropeptide derivative |
| Sequence (Semax) | H-Met-Glu-His-Phe-Pro-Gly-Pro-OH |
| Sequence (XA Semax) | Ac-Met-Glu-His-Phe-Pro-Gly-Pro-NH2 |
| Molecular Weight | Semax ~813 g/mol · XA Semax ~855 g/mol |
| Physical Appearance | White lyophilized powder |
| Purity | >99% (HPLC & Mass Spectrometry verified) |
| Verification Method | HPLC & MS |
| Container | Sterile sealed glass vial; 10 mg |
| Solubility | Soluble in sterile or bacteriostatic water |
| Storage Conditions | 2–8°C; protect from light; long-term −20°C |
| Intended Use | Laboratory research use only (RUO) |
| COA Availability | Lot-specific COA provided per batch |
Potential Research Applications
Semax and XA Semax are studied across a range of CNS research models. XA Semax’s enhanced stability makes it the preferred form for studies requiring prolonged receptor engagement, while standard Semax is used where native-sequence pharmacology is the research focus.
BDNF, NGF, and Neurotrophic Factor Upregulation — Hippocampal and cortical cell-culture and rodent models examining BDNF/TrkB, NGF, and VEGF upregulation via melanocortin/ACTH receptor pathways — one of the most documented activities of Semax-class peptides in the preclinical literature.
Cognitive Function and Memory Research — Animal models of spatial learning, memory consolidation, and attention, with Semax studied in relation to dopaminergic and serotonergic pathway modulation in cortical and hippocampal tissue.
Neuroprotection and Ischemia Models — Rodent models of ischemic brain injury, traumatic CNS damage, and oxidative stress, where Semax-class peptides are studied for their BDNF-mediated neuroprotective and anti-apoptotic signaling.
HPA Axis and Stress-Axis Research — Studies examining HPA axis modulation, cortisol and stress-response pathway regulation, and anxiolytic-like behavioral effects in rodent stress models through ACTH-melanocortin receptor engagement.
FAQ
Find answers to common questions about Semax and XA Semax, their differences, research applications, and purchasing requirements.
Clinically Proven
Why Choose Telos
Every product we ship is engineered to remove variables and let your data speak for itself.
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cGMP Origin
Peptides are produced in ISO-9001 facilities that follow cGMP principles.
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Triple-Filtered
0.22 µm filtration and gamma irradiation safeguard sterility.
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3rd-Party Tested
Each lot is validated by a third-party lab for purity, identity, and endotoxin.
“For Research Only”
Frequently Asked Questions
✧ 1. What are Telos Health peptides used for?
All Telos Health products are sold for research use only. They are not intended for human consumption, therapeutic, or diagnostic use. Our peptides are designed exclusively for controlled laboratory research, educational studies, or analytical testing. Every product label and supporting document clearly reflects this compliance standard.
✦ 2. Who is eligible to purchase peptides?
Purchases are available to verified professionals, licensed clinics, educational institutions, and qualified research entities. Individuals may also purchase peptides for legitimate research or educational purposes, but all buyers must acknowledge and agree to Telos Wellness’s research-only terms prior to completing any order. We do not sell or endorse products for personal or medical use under any circumstance
♡ 3. How should peptides be handled and stored?
Peptides arrive as a lyophilized (freeze-dried) powder. For laboratory reconstitution, use only sterile bacteriostatic water or sterile saline (0.9 percent NaCl). Gently introduce the solvent and swirl—do not shake. Once reconstituted, store at 35°F to 45°F for short-term use, or at –4°F for long-term preservation. Protect vials from light and moisture, and avoid repeated freeze and thaw cycles to maintain stability.
⟡ 4. Why do peptide vials appear nearly empty?
Because peptides are measured in milligrams, the quantity often appears minimal or as a thin layer within the vial. This is completely normal for high-purity research peptides. Each vial undergoes precision weighing and purity testing using high-performance liquid chromatography (HPLC) and mass spectrometry to ensure the correct labeled amount is present.
✧ 5. What documentation and quality assurances come with each product?
Every peptide includes a Certificate of Analysis (COA) verifying its identity, purity (≥ 99 percent), and composition. Each batch is U.S. sourced and assembled under strict quality oversight and internal auditing. Full lot traceability, validated purity testing, and documentation accompany every shipment to ensure reproducibility, compliance, and scientific reliability.