MT-2
$200.00
MT-2 – a cyclic melanocortin receptor agonist for research into pigmentation, energy homeostasis, and neuroendocrine signaling.
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Overview
MT-2 (Melanotan II) is a synthetic cyclic heptapeptide analogue of α-melanocyte-stimulating hormone (α-MSH), an endogenous melanocortin derived from proopiomelanocortin (POMC). MT-2 was developed in the 1980s at the University of Arizona as a superpotent and metabolically stable melanocortin receptor agonist. It acts as a non-selective agonist at melanocortin receptors MC1R through MC4R, with particular affinity for MC3R and MC4R. In preclinical research, MT-2 is studied for its roles in pigmentation (melanogenesis via MC1R), energy homeostasis and appetite regulation (via MC3R/MC4R), and neuroendocrine signaling.
Specification
| CAS Number | 121062-08-6 |
| Chemical Name | Melanotan II; MT-II; cyclo[Nle4, D-Phe7]-α-MSH(4–10) |
| Peptide Type | Synthetic cyclic melanocortin receptor agonist; α-MSH analogue |
| Sequence | Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-NH2 |
| Molecular Formula | C₅₈H₉N₁₅O₁₀ |
| Molecular Weight | 1024.18 g/mol |
| Physical Appearance | White lyophilized powder |
| Purity | >99% (HPLC & Mass Spectrometry verified) |
| Verification Method | HPLC & MS |
| Container | Sterile sealed glass vial; 10 mg |
| Solubility | Soluble in sterile or bacteriostatic water |
| Storage Conditions | 2–8°C; protect from light; long-term −20°C |
| Intended Use | Laboratory research use only (RUO) |
| COA Availability | Lot-specific COA provided per batch |
Potential Research Applications
MT-2 is studied in a range of preclinical models focused on melanocortin receptor biology. As a non-selective MC receptor agonist with high potency, it serves as a standard pharmacological tool in research examining pigmentation, metabolic regulation, and neuroendocrine signaling.
Melanogenesis and Pigmentation Research — Cell-culture models (B16 melanoma, primary melanocytes) examining MC1R-mediated cAMP elevation, tyrosinase activation, and eumelanin synthesis — the core pathway for UV-independent pigmentation research.
Energy Homeostasis and Appetite Regulation Studies — Hypothalamic and rodent models investigating MC3R/MC4R-mediated anorexigenic signaling, energy expenditure modulation, and leptin interaction pathways in obesity and metabolic research.
Neuroendocrine and Behavioral Research — Animal models examining melanocortin system influence on HPA axis reactivity, stress response, and reward circuitry, with MC4R engagement studied in the context of motivation and neuroendocrine feedback loops.
Melanocortin Receptor Pharmacology — Binding affinity and receptor selectivity studies for MC1R–MC5R subtypes, used as a pharmacological reference compound in drug discovery models targeting the melanocortin system.
FAQ
Find answers to common questions about MT-2, its research applications, documentation, and purchasing requirements.
Clinically Proven
Why Choose Telos
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cGMP Origin
Peptides are produced in ISO-9001 facilities that follow cGMP principles.
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Triple-Filtered
0.22 µm filtration and gamma irradiation safeguard sterility.
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3rd-Party Tested
Each lot is validated by a third-party lab for purity, identity, and endotoxin.
“For Research Only”
Frequently Asked Questions
✧ 1. What are Telos Health peptides used for?
All Telos Health products are sold for research use only. They are not intended for human consumption, therapeutic, or diagnostic use. Our peptides are designed exclusively for controlled laboratory research, educational studies, or analytical testing. Every product label and supporting document clearly reflects this compliance standard.
✦ 2. Who is eligible to purchase peptides?
Purchases are available to verified professionals, licensed clinics, educational institutions, and qualified research entities. Individuals may also purchase peptides for legitimate research or educational purposes, but all buyers must acknowledge and agree to Telos Wellness’s research-only terms prior to completing any order. We do not sell or endorse products for personal or medical use under any circumstance
♡ 3. How should peptides be handled and stored?
Peptides arrive as a lyophilized (freeze-dried) powder. For laboratory reconstitution, use only sterile bacteriostatic water or sterile saline (0.9 percent NaCl). Gently introduce the solvent and swirl—do not shake. Once reconstituted, store at 35°F to 45°F for short-term use, or at –4°F for long-term preservation. Protect vials from light and moisture, and avoid repeated freeze and thaw cycles to maintain stability.
⟡ 4. Why do peptide vials appear nearly empty?
Because peptides are measured in milligrams, the quantity often appears minimal or as a thin layer within the vial. This is completely normal for high-purity research peptides. Each vial undergoes precision weighing and purity testing using high-performance liquid chromatography (HPLC) and mass spectrometry to ensure the correct labeled amount is present.
✧ 5. What documentation and quality assurances come with each product?
Every peptide includes a Certificate of Analysis (COA) verifying its identity, purity (≥ 99 percent), and composition. Each batch is U.S. sourced and assembled under strict quality oversight and internal auditing. Full lot traceability, validated purity testing, and documentation accompany every shipment to ensure reproducibility, compliance, and scientific reliability.