TB-500
$200.00
TB-500 – a synthetic Thymosin Beta-4 analogue for research into tissue repair, angiogenesis, and anti-inflammatory pathways.
✓ 99.9% Purity ✓ Lab Tested ✓ Based in USA
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Overview
TB-500 is a synthetic analogue of Thymosin Beta-4 (Tβ4), a 43-amino acid naturally occurring peptide encoded by the TMSB4X gene and found in virtually all nucleated cells. TB-500 corresponds to the actin-binding domain fragment of Tβ4 and is studied for its roles in actin sequestration, lamellipodia formation, and cell migration. In preclinical models, TB-500 has been characterized as a potent mediator of wound healing, angiogenesis, and anti-inflammatory signaling, with documented activity in cardiac, musculoskeletal, ocular, and CNS tissue models.
Specification
| CAS Number | 77591-33-4 |
| Chemical Name | TB-500; Thymosin Beta-4 Fragment; Tβ4(17–23) |
| Peptide Type | Synthetic Thymosin Beta-4 analogue; actin-sequestering peptide fragment |
| Sequence | Ac-Leu-Lys-Lys-Thr-Glu-Thr-Gln-OH (actin-binding domain fragment) |
| Molecular Formula | C₃₈H₆₈N₁₀O₁₄ |
| Molecular Weight | ~4963 g/mol (full TB-500 43-aa analogue) |
| Physical Appearance | White lyophilized powder |
| Purity | >99% (HPLC & Mass Spectrometry verified) |
| Verification Method | HPLC & MS |
| Container | Sterile sealed glass vial; 10 mg |
| Solubility | Soluble in sterile or bacteriostatic water |
| Storage Conditions | 2–8°C; protect from light; long-term −20°C |
| Intended Use | Laboratory research use only (RUO) |
| COA Availability | Lot-specific COA provided per batch |
Potential Research Applications
TB-500 is studied in a broad range of tissue repair and regenerative research models due to its actin-sequestering and pro-migratory properties. Its documented activity in multiple tissue types makes it a versatile research input for wound healing and anti-inflammatory pathway studies.
Wound Healing and Skin Repair Models — Cell-culture and rodent models examining accelerated wound closure, keratinocyte and fibroblast migration, and re-epithelialization, with TB-500 demonstrating upregulation of integrin α4 expression and cell migration signaling.
Musculoskeletal and Tendon Repair Research — Rodent models of muscle injury, tendon repair, and joint inflammation, with studies documenting reduced inflammatory cytokine expression and enhanced tissue regeneration timelines.
Cardiac Tissue Repair Studies — Animal models of myocardial infarction and cardiac injury, where TB-500 has been associated with cardiomyocyte migration, angiogenesis promotion, and cardiac stem cell activation in preclinical settings.
Neuroprotection and Ocular Research — In-vitro and rodent models examining retinal repair, optic nerve regeneration, and CNS injury recovery, with Tβ4-derived peptides showing neuro-migratory and anti-apoptotic properties.
FAQ
Find answers to common questions about TB-500, its research applications, documentation, and purchasing requirements.
Clinically Proven
Why Choose Telos
Every product we ship is engineered to remove variables and let your data speak for itself.
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cGMP Origin
Peptides are produced in ISO-9001 facilities that follow cGMP principles.
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Triple-Filtered
0.22 µm filtration and gamma irradiation safeguard sterility.
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3rd-Party Tested
Each lot is validated by a third-party lab for purity, identity, and endotoxin.
“For Research Only”
Frequently Asked Questions
✧ 1. What are Telos Health peptides used for?
All Telos Health products are sold for research use only. They are not intended for human consumption, therapeutic, or diagnostic use. Our peptides are designed exclusively for controlled laboratory research, educational studies, or analytical testing. Every product label and supporting document clearly reflects this compliance standard.
✦ 2. Who is eligible to purchase peptides?
Purchases are available to verified professionals, licensed clinics, educational institutions, and qualified research entities. Individuals may also purchase peptides for legitimate research or educational purposes, but all buyers must acknowledge and agree to Telos Wellness’s research-only terms prior to completing any order. We do not sell or endorse products for personal or medical use under any circumstance
♡ 3. How should peptides be handled and stored?
Peptides arrive as a lyophilized (freeze-dried) powder. For laboratory reconstitution, use only sterile bacteriostatic water or sterile saline (0.9 percent NaCl). Gently introduce the solvent and swirl—do not shake. Once reconstituted, store at 35°F to 45°F for short-term use, or at –4°F for long-term preservation. Protect vials from light and moisture, and avoid repeated freeze and thaw cycles to maintain stability.
⟡ 4. Why do peptide vials appear nearly empty?
Because peptides are measured in milligrams, the quantity often appears minimal or as a thin layer within the vial. This is completely normal for high-purity research peptides. Each vial undergoes precision weighing and purity testing using high-performance liquid chromatography (HPLC) and mass spectrometry to ensure the correct labeled amount is present.
✧ 5. What documentation and quality assurances come with each product?
Every peptide includes a Certificate of Analysis (COA) verifying its identity, purity (≥ 99 percent), and composition. Each batch is U.S. sourced and assembled under strict quality oversight and internal auditing. Full lot traceability, validated purity testing, and documentation accompany every shipment to ensure reproducibility, compliance, and scientific reliability.